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HomeCDC RecommendationAbout RSVAbout ABRYSVO

About ABRYSVO

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Prescribing InformationIndicationsPatient SiteMaternal
ABRYSVO®: CDC-recommended as a single dose for all adults aged 75 and older and for adults 60-74 years who are at increased risk of severe disease1Risk factors for adults 60-74 include2,3:

Patient attestation is sufficient evidence of the presence of a risk factor. Vaccinators should not deny RSV vaccination to a person because of lack of medical documentation.3

A significant gap in vaccinations means your recommendation matters.3Only an estimated 34% of eligible patients aged 60-74 and 44% of eligible patients aged 75+ are vaccinated for RSV.4*

Discuss vaccination today. Don't wait.

  • Eligible adults that remain unvaccinated can get an RSV vaccine at any time of year, but the best time to get vaccinated is late summer to early fall (August to October)

According to the CDC, RSV vaccines can be given simultaneously with any of the following vaccines2:

  • Seasonal influenza vaccines
  • COVID-19 vaccines
  • Recombinant zoster vaccine
  • Seasonal influenza vaccines
  • COVID-19 vaccines
  • Recombinant zoster vaccine
  • Pneumococcal vaccines
  • Td/Tdap vaccines
  • Pneumococcal vaccines
  • Td/Tdap vaccines
  • Available data on immunogenicity of coadministration of RSV vaccines and other vaccines are currently limited

ABRYSVO can be coadministered with the seasonal influenza vaccine2,5:

  • Coadministration of ABRYSVO and influenza vaccine, adjuvanted (FLUAD QUADRIVALENT), demonstrated non-inferiority compared with sequential administration in adults aged 65 and older
  • – Fatigue reported in 30% (coadministration), 19.1% (ABRYSVO alone), and 27.1% (flu alone) of participants
  • – No SAEs were related to vaccination, and no additional safety concerns were identified

ReferencesData from RSVVaxView, as of December 28, 2024.CDC=Centers for Disease Control and Prevention; CKD=chronic kidney disease; RSV=respiratory syncytial virus; SAE=serious adverse event; Td=tetanus-diphtheria; Tdap=tetanus, diphtheria, and pertussis.References
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Order ABRYSVOLoadingLearn about RSVLoadingA significant gap in vaccinations means your recommendation matters.3Only an estimated 34% of eligible patients aged 60-74 and 44% of eligible patients aged 75+ are vaccinated for RSV.4*
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References:Centers for Disease Control and Prevention (CDC). RSV vaccine guidance for older adults. August 30, 2024. Accessed December 11, 2024.
https://www.cdc.gov/rsv/hcp/vaccine-clinical-guidance/older-adults.htmlMelgar M, Britton A. ACIP adult RSV work group clinical considerations. Centers for Disease Control and Prevention. Published June 26, 2024. https://www.cdc.gov/acip/downloads/slides-2024-06-26-28/12-rsv-adult-melgar-508.pdfBritton A, Roper LE, Kotton CN, et al. Use of respiratory syncytial virus vaccines in adults aged ≥60 years: updated recommendations of the Advisory Committee on Immunization Practices - United States, 2024. MMWR Morb Mortal Wkly Rep. 2024;73(32):696-702.Centers for Disease Control and Prevention (CDC). Respiratory syncytial virus (RSV) vaccination coverage and intent for vaccination, adults 60 years and older. November 30, 2024. Accessed December 11, 2024. https://www.cdc.gov/rsvvaxview/dashboard/adults-60-coverage-intent.htmlABRYSVO (Respiratory Syncytial Virus Vaccine) Prescribing Information. Pfizer Inc; January 2025.

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PP-A1G-USA-2260
IndicationsABRYSVO is a vaccine indicated for:
  • active immunization for the prevention of lower respiratory tract disease (LRTD) caused by respiratory syncytial virus (RSV) in individuals 60 years of age and older
  • active immunization of pregnant individuals at 32 through 36 weeks gestational age for the prevention of LRTD and severe LRTD caused by RSV in infants from birth through 6 months of age
  • active immunization for the prevention of LRTD caused by RSV in individuals 18 through 59 years of age who are at increased risk for LRTD caused by RSV
Please click here for full Prescribing Information.
Important Safety Information
  • Do not administer ABRYSVO to individuals with a history of a severe allergic reaction (e.g., anaphylaxis) to any component of ABRYSVO
  • The results of a postmarketing observational study suggest an increased risk of Guillain-Barré syndrome during the 42 days following vaccination with ABRYSVO
  • A numerical imbalance in preterm births was observed compared to placebo in 2 clinical studies. Data are insufficient to establish or exclude a causal relationship between preterm birth and ABRYSVO. To avoid potential risk of preterm birth with use of ABRYSVO before 32 weeks of gestation, administer to pregnant individuals at 32 through 36 weeks gestational age
  • Appropriate medical treatment must be available in case of an anaphylactic reaction
  • Syncope (fainting) may occur in association with administration of injectable vaccines, including ABRYSVO. Procedures should be in place to avoid injury from fainting
  • Immunocompromised individuals, including those receiving immunosuppressive therapy, may have a diminished immune response to ABRYSVO
  • Vaccination with ABRYSVO may not protect all vaccine recipients
  • In clinical trials with adults aged 60+, the most commonly reported (≥10%) adverse reactions
were fatigue (15.7%), headache (12.9%), pain at the injection site (10.7%), and muscle pain (10.2%)
  • In clinical trials with adults aged 18-59, the most commonly reported (≥10%) adverse reactions were pain at the injection site (35.3%), muscle pain (24.4%), joint pain (12.4%), and nausea (11.8%)
  • In clinical trials with pregnant individuals, the most commonly reported (≥10%) adverse reactions
were pain at the injection site (40.6%), headache (31.0%), muscle pain (26.5%), and nausea (20.0%)
  • In clinical trials with infants born to pregnant individuals, low birth weight (5.1% ABRYSVO versus 4.4% placebo) and neonatal jaundice (7.2% ABRYSVO versus 6.7% placebo) were observed
Individuals who received ABRYSVO during pregnancy are encouraged to contact 1-800-616-3791 to enroll in a Pregnancy Exposure Registry.

Patients should always ask their healthcare providers for medical advice about adverse events. You are encouraged to report negative side effects of vaccines to the US Food and Drug Administration (FDA) and the Centers for Disease Control and Prevention (CDC). Visit http://www.vaers.hhs.gov or call 1-800-822-7967.

Please see full Prescribing Information for ABRYSVO.IndicationsABRYSVO is a vaccine indicated for:
  • active immunization for the prevention of lower respiratory tract disease (LRTD) caused by respiratory syncytial virus (RSV) in individuals 60 years of age and older
     
  • active immunization of pregnant individuals at 32 through 36 weeks gestational age for the prevention of LRTD and severe LRTD caused by RSV in infants from birth through 6 months of age
     
  • active immunization for the prevention of LRTD caused by RSV in individuals 18 through 59 years of age who are at increased risk for LRTD caused by RSV
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